RO5166017 is a potent, orally active agonist of the trace amine-associated receptor 1 (TAAR1) used as a research tool in preclinical pharmacology. It exhibits low-nanomolar activity in rodent TAAR1 and measurable activity at human TAAR1, and the product datasheet provides purity, solubility, and storage guidance for experimental use.
- Orally active TAAR1 agonist with nanomolar potency.
- Binding Ki values: mouse 1.9 nM, rat 2.7 nM, human 31 nM, cynomolgus 24 nM.
- High purity, reported as about 99.4%.
- Molecular formula C12H17N3O; molecular weight 219.29 g/mol.
- Soluble in DMSO (25 mg/mL); in vivo formulation options and concentrations provided.
- Storage recommendations: -20°C for solid; in solvent, -80°C for long-term storage.